Endocrine Abstracts

Introduction: Oral levothyroxine (L-T4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper L-T4 dose. The absorption and bioequivalence of different commercial L-T4 preparations might be variable. The aim of this study is to compare the efficacy of L-T4 using alternating doses vs fixed ones.Me...

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

Background: Adrenal insufficiency (AI) results from deficient production/action of glucocorticoids (GCs), with or without deficiency of mineralocorticoids (MC) and adrenal androgens. GC treatment is essential but some patient needs MC therapy to allow sodium(Na+) retention, potassium(K+) excretion and to maintain normal plasma volume and blood pressure. Much attention has focused on optimization of GC replacement but no consensus exists for optimization o...